Groups A to D are in the spotlight on Wednesday with European powerhouses Bayern Munich and Real Madrid looking to seal their places in the last 16.
Bayern have won all three group games so far and should be able to punch their ticket to the knockout rounds with a win at home to Galatasaray.
Madrid are also three from three in Group C and should have few problems from Braga, who have won just once in the competition this season.
Arsenal can put one foot in the next round when they take on a Sevilla side they beat 2-1 last time out in the competition, but Manchester United have much more work to do and only a win can keep alive their hopes of qualification when they head to Copenhagen.
- Bayern Munich to win & over 3.5 goals vs Galatasaray
- Arsenal to win & both teams to score vs Sevilla
- Real Sociedad to beat Benfica
- Napoli to win to nil vs Union Berlin
Bayern Munich vs Galatasaray
Bayern Munich warmed up for this contest with a thumping 4-0 win over Borussia Dortmund in the Bundesliga and they should qualify for the last 16 of the Champions League in a high-scoring contest against the Turkish champions.
However, Gala head for Bavaria in great nick themselves, and they will be no pushovers at the Allianz Arena having gone ten away games unbeaten in European competitions.
Their domestic form is also impressive and they have won 10 games on the bounce as they look to land their 24th league title. They have picked up 31 points from a possible 33 and they have won eight of their last nine matches in all competitions.
So Bayern will need to be on their guard, but with Harry Kane in such fine form, and his supporting cast also hitting their straps, a home victory looks more than likely.
Bayern beat Galatasaray 3-1 when they met on matchday three and a similar outcome looks likely in Munich this week, with goals again expected.
Thomas Tuchel's men have won their last three home league matches by an aggregate 18-0 and they put four past Manchester United in a 4-3 thriller on matchday one.
Bayern will need a defensive reshuffle with Matthijs de Ligt ruled out and that could offer a glimmer of hope to the visitors to at least get on the scoresheet, so back Bayern to prevail in a high-scoring encounter.
Arsenal vs Sevilla
Arsenal lost their unbeaten start to the Premier League season with a defeat at Newcastle on Saturday, but they can get back to winning ways against Sevilla and edge closer to the knockout stages.
The Gunners are top of Group B, one point ahead of Lens, but they are three clear of Sevilla who could struggle to qualify if they lose this week and Lens get the better of PSV.
Mikel Arteta will be concentrating only on his own side doing their job and they will be confident of another victory over the Spanish outfit having won 2-1 in Seville on matchday three.
Arsenal are unbeaten in seven home matches in all competitions this season, and they have scored in their last 20 Champions League group-stage matches.
So at least one home goal can be expected, and it would be folly to rule out an away goal as Sevilla have scored in six of their eight matches on the road in all competitions this season. Having scored in 14 of their 16 outings in this campaign it may be tricky for the north Londoners to keep them out.
Backing an Arsenal win with both teams scoring looks the best course of action.
Real Sociedad vs Benfica
Real Sociedad have lost only two of their last 19 European group-stage matches and they should be backed to do the double over Portuguese giants Benfica on Wednesday.
La Real beat Benfica 1-0 in Lisbon last time out in this competition and they are a formidable force at the Reale Arena where they have lost just once this term, to Spanish champions Barcelona.
That ended a four-match unbeaten run for Sociedad who lead the way in Champions League Group D and the Spanish side can all-but seal their place in the last 16 with a victory here.
Sociedad have won only five of their last 17 home European games but history suggests they can improve that figure this week.
And history isn't on Benfica's side as they head to Spain.
The Portuguese giants are one of just two teams in this season's Champions League, along with AC Milan, who have lost each of their first three group-stage games without scoring, and they are on the cusp of exiting at the first hurdle for the seventh time in the last 11 years.
Benfica, who have won just two of their last 20 meetings with Spanish opposition, know that anything other than a victory on Wednesday will prevent them from securing a top-two finish in Group D as they sit seven points adrift of Sociedad and Inter with three games remaining.
Their fate could be sealed this week with a home win looking the best bet on Wednesday.
Napoli vs Union Berlin
Union Berlin have lost their last 12 matches in all competitions and their Champions League adventure looks set to end with another defeat this week.
They enter the bear pit that is the Diego Armando Maradona Stadium in Naples to take on Italian champions Napoli, who are looking to edge closer to the last 16.
Things haven't gone too smoothly for the Italians, who strolled to the domestic title last season, but they are unbeaten in their last four matches, winning three, and they are second to Real Madrid in Group C of this competition.
It was 1-0 to Napoli when these two last met on matchday three last month, and the Italians should be backed to win while keeping a clean sheet against their beleaguered opponents again this week.